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The other method is based on use of geotechnical engineering techniques at sites of marginal liquefaction, in order to bracket the peak accelerations as a function of epicentral distance; these accelerations can then be compared with predictions from seismological models.

Computational Medicine Research Team is homed at three institutions.

Liquefaction features can be used in many field settings to estimate the recurrence interval and magnitude of strong earthquakes through much of the Holocene.

These features include dikes, craters, vented sand, sills, and laterally spreading landslides.

Interestingly, in comparison to the current expenditure on genome-wide arrays, the cost of the quantitative serum NMR metabolomics is only around one-third.

It is therefore no longer unrealistic to envision that quantitative metabolomics would be incorporated as a routine for all serum samples in large biobanks and epidemiological cohorts; this would make perfect sense both from the biological research and cost point of view – the standard output of over 200 molecular measures would vastly extend the biomedical relevance of the sample collections.

In Kuopio we focus on the experimental NMR analyses of serum and other biological samples as well as advanced spectral analysis.We have pioneered the development and applications of quantitative high-throughput serum NMR metabolomics in molecular epidemiology and genetics via a novel serum NMR metabolomics platform developed by the Team in Finland.This methodology has been used to analyse close to 200,000 blood specimens.Kuopio is the key site for our R&D of new experimental metabolomics methodologies.Collaboration with IEU, a large alliance of research excellence at the University of Bristol, led by Professor George Davey Smith, is bringing in a wide variety of expertise in systems epidemiology.